Metabolic syndrome (MS) is one of the most prevalent diseases in the world; around the 24% of the adult population suffer it. The MS is a cluster of dysmetabolic features that can originate issues like central obesity, hyperglycemia, hypertension, hypercholesterolemia and/or diabetes Mellitus (also known as type II). The causes of the MS are unknown because it is an extremely complex physiopathology but it is related with people who suffer obesity, sedentary life and insulin resistance. Furthermore, the MS is related with an increased risk for age-related cognitive deterioration. For this reason, developing an efficacious preventative and/or therapeutic intervention for MS and resulting brain impairments has fundamental importance.
Dietary polyphenols and other compounds are considered as potential therapeutic agents to treat obesity-mediated inflammation and oxidative stress and also other MS-related diseases (Diabetes II, hypertension…) due to their beneficial properties such as: antioxidant, anti-inflammatory, antibiotic, cardio protective and anti-neurodegenerative effects. In this study, special attention is paid to the polyphenols present in grape pomace, extracted from winemaking residues, which is our raw material.
Polyphenols can be found in several types of fruits and vegetables: berries, grapes, tea, beer, olive oil or cocoa. They are characterized by the presence, at least, of one aromatic ring bearing one or more hydroxyl substituents. The polyphenols can be classified as shown in Figure 1.
The main objective of this study is the development of a green and sustainable fractionation and separation process for the recovery from winemaking residues of phenolic compounds with strong bioactivity on different metabolic syndrome biomarkers. The fractions/extracts obtained along the study will be evaluated by their bioactivity against MS through human cell-based and enzymatic assays. The extracts developed could be applied as natural ingredient for the prevention or adjuvant treatment of MS and reduce its associated diseases.
This project has just started and it is encouraging due to the possibility to confront one of the most prevalent health issues in the world, without forgetting that a big amount of wastes derived from winemaking could be used as a raw material.
Rut Romero – Project WineSense