Research on extraction and formulation intensification processes for natural actives of wine

27/05/2015
by TMR
Comments Off on [NEW PAPER] Production of water soluble quercetin formulations by pressurized ethyl acetate-in-water emulsion technique

[NEW PAPER] Production of water soluble quercetin formulations by pressurized ethyl acetate-in-water emulsion technique

vanessa-paper

Quercetin is a strong antioxidant flavonoid with several bioactive properties such as anti-inflammatory and anticarcinogenic activities, becoming an interesting compound to be incorporated into pharmaceutical, cosmetic or food products. However, these applications are limited by the low bioavailability of this flavonoid. Quercetin is poorly soluble in aqueous media, such as gastrointestinal fluids, being also degraded by gut flora. Thus, it is necessary the development of quercetin’s formulations capable of improving its water solubility resulting in increased bioavailability and thus higher biological activity of this compound. Continue Reading →

07/05/2015
by TMR
Comments Off on Development of a quercetin-based cosmetic booster: a market study

Development of a quercetin-based cosmetic booster: a market study

quercetin edit

Óscar Benito has recently rejoined our group after a 7 month stay in FeyeCon Development & Implementation (Netherlands) as part of the WineSense project. During this time he worked on the product development based on quercetin aqueous microdispersions. The selected product was a booster of quercetin (a cosmetic product highly concentrated in the active principle, quercetin in this case). The work was divided in three stages: Continue Reading →

06/05/2015
by TMR
Comments Off on HPP group at Marie Sklodowska-Curie Actions event

HPP group at Marie Sklodowska-Curie Actions event

María José Cocero, head of the High Pressure Processes Group, was invited as a speaker at the HORIZON 2020: MARIE SKLODOWSKA-CURIE ACTIONS event organized by the University of Valladolid on April 29 2015. She presented two of the group’s projects as “success cases”: WineSense (Research on extraction and formulation intensification processes for natural actives of wine, part of the Marie Curie Industry-Academia Partnerships and Pathways) and DoHip (Training program for the design of resource and energy efficient products by high pressure processes, part of the Innovative Training Networks).

marie curie

You can download the presentation here.

27/04/2015
by TMR
Comments Off on Adsorption/desorption characteristics and purification of polyphenols from grapes using macroporous resins

Adsorption/desorption characteristics and purification of polyphenols from grapes using macroporous resins

ana matiasGrape fruit contains various nutrient elements, such as vitamins, minerals, carbohydrates, edible fibers and phytochemicals. Polyphenols are the most important phytochemicals in grape because they possess many biological activities and health-promoting benefits. The phenolic compounds mainly include anthocyanins, flavanols, flavonols, stilbenes (resveratrol) and phenolic acids. Anthocyanins are pigments, and mainly exist in grape skins. Flavonoids are widely distributed in grapes, especially in seeds and stems, and principally contain (+)-catechins, (−)-epicatechin and procyanidin polymers. Anthocyanins are the main polyphenolics in red grapes, while flavan-3-ols are more abundant in white varieties. Continue Reading →

16/03/2015
by TMR
Comments Off on Development of a novel process for the selective recovery of polyphenolic compounds from winemaking residues for the treatment and prevention of metabolic syndrome

Development of a novel process for the selective recovery of polyphenolic compounds from winemaking residues for the treatment and prevention of metabolic syndrome

rut2Metabolic syndrome (MS) is one of the most prevalent diseases in the world; around the 24% of the adult population suffer it. The MS is a cluster of dysmetabolic features that can originate issues like central obesity, hyperglycemia, hypertension, hypercholesterolemia and/or diabetes Mellitus (also known as type II). The causes of the MS are unknown because it is an extremely complex physiopathology but it is related with people who suffer obesity, sedentary life and insulin resistance. Furthermore, the MS is related with an increased risk for age-related cognitive deterioration. For this reason, developing an efficacious preventative and/or therapeutic intervention for MS and resulting brain impairments has fundamental importance. Continue Reading →

23/12/2014
by TMR
Comments Off on – Job – Postdoctoral Research Position opened – 12 months

– Job – Postdoctoral Research Position opened – 12 months

winesense People logomariecurie

Postdoctoral Research Position at iBET

In transfer of knowledge in process and products development on extraction and formulation intensification processes for natural actives of wine.

The position is funded by the European Commission under the Marie Curie Industrial and Academia Partnership and Pathway (IAPP) PIAP-GA-2013-612208, project WineSense.

Deadline:   16th January 2015 or till the position is filled

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10/11/2014
by TMR
Comments Off on Kinetic Analysis Of Microwave Assisted Extraction Of Polyphenols From Grape Pomace

Kinetic Analysis Of Microwave Assisted Extraction Of Polyphenols From Grape Pomace

ana1

Figure 1. Temperature profiles for the different extraction processes

Polyphenols are considered as high value products by cosmetic and food industry due to, mainly, their great antioxidant power. Therefore, new extraction techniques have been investigated in recent years in order to find how to preserve the extract quality during the process. Microwave assisted extraction has been found to provide good results. It allows to reduce extraction time and the amount of solvent required. However, during this work, microwave radiation has been used as a pretreatment for a conventional process: instead of irradiating the sample up to a mild temperature (difficult industry implementation), an intensive pretreatment has been employed. In it, temperature is raised up to close to the solvent’s boiling point by a short microwave pulse; then, the sample is rapidly cooled down and undergoes a brief solid-liquid conventional extracion. An innovative aspect of this research is that the combination of microwaves and pressure has also been studied. As pressure increases, solvent boiling point rises too. This enables extraction to be carried out at a higher temperature, and in consequence, extraction kinetices are accelerated. Continue Reading →

14/03/2014
by TMR
Comments Off on – Job – Postdoctoral Research Position opened – 24 months

– Job – Postdoctoral Research Position opened – 24 months

winesense People logomariecurie

In transfer of knowledge in process and products development on Extraction and formulation intensification processes for natural actives of wine.

The position is funded by the European Commission under the Marie Curie Industrial and Academia Partnership and Pathway (IAPP) PIAP-GA-2013-612208, project WineSense.

Deadline:   April 7th, 2014

– EURAXESS: http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/33909687
– OPEUVA: http://funge.uva.es/area-innovacion/winesense/
– HPP: http://hpp.uva.es/job-postdoctoral-research-position-opened-24-months

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23/01/2014
by TMR
Comments Off on Meet Vanessa Gonçalves – an early stage researcher from WineSense project that is with us since January

Meet Vanessa Gonçalves – an early stage researcher from WineSense project that is with us since January

Vanessa is the first early stage researcher to come to High Pressure Processes Group in Valladolid within the framework of the WineSense project. She comes from Instituto De Biologia Experimental E Tecnológica (iBET, Portugal) and during her nine months of stay she will evaluate different carriers as suitable materials for the encapsulation of polyphenols with distinct polarities.

Vanessa Gonçalves (MSc Pharm Sciences, 2010) is also doing her PhD in Pharmaceutical Technology (IBET/ITQB-UNL – Portugal) under the supervision of Dr. Catarina Duarte and co-supervision of Dr. Ana Matias with the thesis “Overcoming Central Nervous System-barriers by the development of hybrid nanostructured systems for nose-to-brain drug delivery using precipitation clean technologies” (SFRH/BD/77350/2011).

The main aim of her thesis project is to develop multilayered and hybrid nanostructures, with mucoadhesive properties, through one- or multi-step supercritical precipitation techniques. These drug delivery systems could be further used for nose-to-brain drug delivery.

 Braintonose

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